A Study Comparing the Efficacy and Safety of Etrolizumab With Adalimumab and Placebo in Participants With Moderate to Severe Ulcerative Colitis (UC) in Participants Naive to Tumor Necrosis Factor (TNF) Inhibitors (Study #1)

Study Purpose

This Phase III, double blind, placebo and active comparator controlled, multicenter study will investigate the efficacy and safety of etrolizumab in induction of remission in participants with moderately to severely active UC who are naIve to TNF inhibitors and refractory to or intolerant of prior immunosuppressant and/or corticosteroid treatment.

Recruitment Criteria

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Accepts Healthy Volunteers
No

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Study Type
Interventional
Eligible Ages 18 Years - 80 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

- Diagnosis of UC established at least 3 months prior to randomization (Day 1) - Moderately to severely active UC as determined by the MCS - Naive to treatment with TNF inhibitor therapy - An inadequate response, loss of response, or intolerance to prior corticosteroid and/or immunosuppressant treatment - Background UC therapy may include oral 5-aminosalisylate (ASA), oral corticosteroids, budesonide, probiotics, azathioprine (AZA), 6-mercaptopurine (MP), or methotrexate (MTX) if doses have been stable for the 8 weeks immediately prior to randomization - Use of highly effective contraception method as defined by the protocol - Have received a colonoscopy within the past year or be willing to undergo a colonoscopy in lieu of a flexible sigmoidoscopy at screening

Exclusion Criteria:

- A history of or current conditions and diseases affecting the digestive tract, such as indeterminate colitis, suspicion of ischemic, radiation or microscopic colitis, Crohn's disease, fistulas or abdominal abscesses, colonic mucosal dysplasia, stricture (stenosis) of the colon, toxic megacolon, or unremoved adenomatous colonic polyps - Prior or planned surgery for UC - Past or present ileostomy or colostomy - Have received non-permitted inflammatory bowel disease (IBD) anti-integrin therapies (including natalizumab, vedolizumab, and efalizumab) as stated in the protocol - Any prior treatment with anti-adhesion molecules (e.g., anti-mucosal addressin cell adhesion molecule-1 [anti-MAdCAM-1]) - Congenital or acquired immune deficiency, chronic hepatitis B or C infection, HIV positive - Evidence of or treatment for Clostridium difficile within 60 days prior to randomization or other intestinal pathogens within 30 days prior to randomization - History of active or latent tuberculosis (TB), recurrent opportunistic infections, severe disseminated viral infections and organ transplant - Any major episode of infection requiring treatment with intravenous (IV) antibiotics within 8 weeks prior to screening or oral antibiotics within 4 weeks prior to screening - Received a live attenuated vaccine within 4 weeks prior to randomization

Trial Details

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

Trial ID:
NCT02163759

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase
Phase 3

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Lead Sponsor
Hoffmann-La Roche

The person who is responsible for the scientific and technical direction of the entire clinical study.

Principal Investigator
Clinical Trials
Principal Investigator Affiliation Hoffmann-La Roche

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Agency Class
Industry
Overall Status Recruiting
Countries Argentina, Australia, Brazil, Bulgaria, Estonia, Hong Kong, Mexico, Poland, Russian Federation, Serbia, Slovakia, Ukraine, United States

The disease, disorder, syndrome, illness, or injury that is being studied.

Conditions
Ulcerative Colitis

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Preferred Research Partners, Inc., Little Rock, Arkansas

Status

Withdrawn

Address

Preferred Research Partners, Inc.

Little Rock, Arkansas, 72211

Garden Grove, California

Status

Withdrawn

Address

Digestive and Liver Disease Specialists; A Medical Group, Inc.

Garden Grove, California, 92840

Mission Viejo, California

Status

Recruiting

Address

Orange County Institute of Gastroenterology & Endoscopy

Mission Viejo, California, 92691

Sutter Institute for Medical Research, Roseville, California

Status

Withdrawn

Address

Sutter Institute for Medical Research

Roseville, California, 95661

Precision Research Institute, LLC, San Diego, California

Status

Terminated

Address

Precision Research Institute, LLC

San Diego, California, 92114

Lakewood, Colorado

Status

Completed

Address

Rocky Mountain Gastroenterology Associates, P.L.L.C.; Gastroenterology

Lakewood, Colorado, 80215

Hollywood, Florida

Status

Terminated

Address

The Center for Gastrointestinal Disorders

Hollywood, Florida, 33021

Florida Center for Gastroenterology, Largo, Florida

Status

Terminated

Address

Florida Center for Gastroenterology

Largo, Florida, 33777

Center for Advanced Gastroenterology, Maitland, Florida

Status

Completed

Address

Center for Advanced Gastroenterology

Maitland, Florida, 32751

Advanced Clinical Research of Miami, Miami, Florida

Status

Withdrawn

Address

Advanced Clinical Research of Miami

Miami, Florida, 33155

Gastroenterology Group of Naples, Naples, Florida

Status

Recruiting

Address

Gastroenterology Group of Naples

Naples, Florida, 34102

Center For Digestive Health, Orlando, Florida

Status

Not yet recruiting

Address

Center For Digestive Health

Orlando, Florida, 32803

International Clinical Research, Sanford, Florida

Status

Withdrawn

Address

International Clinical Research

Sanford, Florida, 32771

Macon, Georgia

Status

Recruiting

Address

Gastroenterology Associates of Central Georgia

Macon, Georgia, 31201

University of Chicago Medical Center, Chicago, Illinois

Status

Recruiting

Address

University of Chicago Medical Center

Chicago, Illinois, 60637

Carle Foundation, Urbana, Illinois

Status

Terminated

Address

Carle Foundation

Urbana, Illinois, 61801

University of Louisville, Louisville, Kentucky

Status

Terminated

Address

University of Louisville

Louisville, Kentucky, 40202-1798

Gastroenterology Associates, LLC, Baton Rouge, Louisiana

Status

Recruiting

Address

Gastroenterology Associates, LLC

Baton Rouge, Louisiana, 70809

Boston, Massachusetts

Status

Withdrawn

Address

Massachusetts General Hospital; Crohn's & Colitis Center

Boston, Massachusetts, 02114

Center for Digestive Health, Troy, Michigan

Status

Recruiting

Address

Center for Digestive Health

Troy, Michigan, 48098

Huron Gastroenterology Associates, Ypsilanti, Michigan

Status

Recruiting

Address

Huron Gastroenterology Associates

Ypsilanti, Michigan, 48197

Gastroenterology Group of South Jersey, Vineland, New Jersey

Status

Terminated

Address

Gastroenterology Group of South Jersey

Vineland, New Jersey, 08360

Charlotte, North Carolina

Status

Terminated

Address

Charlotte Gastroenterology and Hepatology, P.L.L.C

Charlotte, North Carolina, 28207

Clinical Trials of North Carolina, LLC, Durham, North Carolina

Status

Withdrawn

Address

Clinical Trials of North Carolina, LLC

Durham, North Carolina, 27705

UC Health, LLC., Cincinnati, Ohio

Status

Recruiting

Address

UC Health, LLC.

Cincinnati, Ohio, 45267

OU Health Science Center GI, Oklahoma City, Oklahoma

Status

Withdrawn

Address

OU Health Science Center GI

Oklahoma City, Oklahoma, 73104-5020

Northwest Gastroenterology Clinic, Portland, Oregon

Status

Terminated

Address

Northwest Gastroenterology Clinic

Portland, Oregon, 97210

ClinSearch, LLC, Chattanooga, Tennessee

Status

Terminated

Address

ClinSearch, LLC

Chattanooga, Tennessee, 37421

Arlington, Texas

Status

Withdrawn

Address

Texas Physicians Medical Research Group, LLC; Gastroenterology

Arlington, Texas, 76002

Wellness Clinical Research Center, San Antonio, Texas

Status

Recruiting

Address

Wellness Clinical Research Center

San Antonio, Texas, 78232

Tyler Research Institute, LLC, Tyler, Texas

Status

Recruiting

Address

Tyler Research Institute, LLC

Tyler, Texas, 75701

Advanced Research Institute, Ogden, Utah

Status

Terminated

Address

Advanced Research Institute

Ogden, Utah, 84405

International Sites

Durango, Mexico

Status

Terminated

Address

Nucleo Victoria de Investigacion Clinica S.C.

Durango, , 34000

Leon, Mexico

Status

Terminated

Address

Centro de Investigacion Farmacologica del Bajio, S.C.

Leon, , 37520

Accelerium S. de R.L. de C.V., Monterrey, Mexico

Status

Recruiting

Address

Accelerium S. de R.L. de C.V.

Monterrey, , 64000

Monterrey, Mexico

Status

Active, not recruiting

Address

Hospital Universitario Dr Jose Eleuterio Gonzalez; Universidad Autónoma de Nuevo León

Monterrey, , 64460

Morelia, Mexico

Status

Terminated

Address

Centro de Investigacion Clinica Chapultepec S. A. de C. V.

Morelia, , 58260

Saluz Investigacion SC, Veracruz, Mexico

Status

Withdrawn

Address

Saluz Investigacion SC

Veracruz, , 91910

Bialystok, Poland

Status

Not yet recruiting

Address

Uniwersytecki Szpital Kliniczny w Bialymstoku

Bialystok, , 15-276

Centrum Medyczne Sw. Lukasza, Częstochowa, Poland

Status

Recruiting

Address

Centrum Medyczne Sw. Lukasza

Częstochowa, , 42-202

Gdansk, Poland

Status

Completed

Address

7 Szpital Marynarki Wojennej z Przychodnia SPZOZ im. W. Lasinskiego

Gdansk, , 80-305

NZOZ Centrum Medyczne ProMiMed, Krakow, Poland

Status

Recruiting

Address

NZOZ Centrum Medyczne ProMiMed

Krakow, , 31-637

Lodz, Poland

Status

Withdrawn

Address

Centrum Terapii Wspolczesnej J.M.Jasnorzewska Spolka Komandytowo-Akcyjna

Lodz, , 90-242

Lodz, Poland

Status

Withdrawn

Address

NZOZ Centrum Medyczne Szpital Sw. Rodziny

Lodz, , 90-302

Med-Gastr Przychodnia Specjalistyczna, Lodz, Poland

Status

Completed

Address

Med-Gastr Przychodnia Specjalistyczna

Lodz, , 91-034

Lublin, Poland

Status

Recruiting

Address

Indywidualna Specjalistyczna Praktyka Lekarska

Lublin, , 20-015

GASTROMED Sp. z o.o., Lublin, Poland

Status

Recruiting

Address

GASTROMED Sp. z o.o.

Lublin, , 20-582

Olsztyn, Poland

Status

Recruiting

Address

Wojewodzki Specjalistyczny Szpital w Olsztynie

Olsztyn, , 10-561

SOLUMED Centrum Medyczne, Poznań, Poland

Status

Recruiting

Address

SOLUMED Centrum Medyczne

Poznań, , 60-529

Sopot, Poland

Status

Recruiting

Address

Specjalistyczna Praktyka Lekarska Dr med. Marek Horynski; endoskopia

Sopot, , 81-756

Szczecin, Poland

Status

Recruiting

Address

Twoja Przychodnia-Szczecinskie Centrum Medyczne

Szczecin, , 71-270

Torun, Poland

Status

Withdrawn

Address

Indywidualna Spec.Praktyka Lek. w Dziedzinie Chirurgii Ogolnej i Gastroenterologii

Torun, , 87-100

Centrum Zdrowia MDM, Warszawa, Poland

Status

Recruiting

Address

Centrum Zdrowia MDM

Warszawa, , 00-635

Warszawa, Poland

Status

Recruiting

Address

Centrum Onkologii-Instytut im. M. Sklodowskiej Curie

Warszawa, , 02-781

Wroclaw, Poland

Status

Recruiting

Address

Ars-Medica S.C Rybak Maria, Rybak Zbigniew

Wroclaw, , 53-333

EMC Instytut Medyczny S.A., Wroclaw, Poland

Status

Recruiting

Address

EMC Instytut Medyczny S.A.

Wroclaw, , 54-144

Wroclaw, Poland

Status

Not yet recruiting

Address

EuroMediCare Szpital Specjalistyczny z Przychodnią we Wrocławiu

Wroclaw, , 54-144

Baltic Medicine, St.Petersburg, Leningrad, Russian Federation

Status

Recruiting

Address

Baltic Medicine

St.Petersburg, Leningrad, 194356

Moscow, Moskovskaja Oblast, Russian Federation

Status

Terminated

Address

SBEI HPE " First Moscow State Medical University n.a. I.M. Sechenov" of the MoH of the RF

Moscow, Moskovskaja Oblast, 119992

Pushkin, Sankt Petersburg, Russian Federation

Status

Recruiting

Address

Private Medical Institution "Evromedservis"

Pushkin, Sankt Petersburg, 196603

Sankt-peterburg, Sankt Petersburg, Russian Federation

Status

Recruiting

Address

SPb SBIH "City Multy-field Hospital # 2"; Intensive Pulmonology and Thoracal Surgery

Sankt-peterburg, Sankt Petersburg, 194354

Cherepovets, Vologda, Russian Federation

Status

Not yet recruiting

Address

Medical and Sanitary Division of Severstal

Cherepovets, Vologda, 162600

Kazan, Russian Federation

Status

Terminated

Address

SBEI HPE "Kazan State Medical University" of the MoH of the RF

Kazan, , 420064

FSBIH Central Clinical Hospital of RAS, Moscow, Russian Federation

Status

Recruiting

Address

FSBIH Central Clinical Hospital of RAS

Moscow, , 119333

Moscow, Russian Federation

Status

Active, not recruiting

Address

FSBI "State Scientific Centre of Coloproctology" of the MoH of RF; Gastroenterology

Moscow, , 123154

Moscow, Russian Federation

Status

Not yet recruiting

Address

LEC at SBIH of Moscow "City Clinical Hospital # 24"

Moscow, , 127015

Nizhny Novgorod, Russian Federation

Status

Recruiting

Address

SBHI of NN region "RCH of NN n.a. N.A.Semashko"

Nizhny Novgorod, , 603126

Omsk, Russian Federation

Status

Recruiting

Address

SBEI of HPE "Omsk SMA" Ministry of healthcare of RF"

Omsk, , 644043

SEIHPE "Rostov SMU of MoH of RF", Rostov-on-Don, Russian Federation

Status

Recruiting

Address

SEIHPE "Rostov SMU of MoH of RF"

Rostov-on-Don, , 344022

Samara, Russian Federation

Status

Not yet recruiting

Address

NonState Healthcare Institution Central Clinical Hospital, Samara station JSC "Russian Railways"

Samara, ,

SBHI of city of Sochi City Hospital #5, Sochi, Russian Federation

Status

Terminated

Address

SBHI of city of Sochi City Hospital #5

Sochi, , 354207

City Hospital #26, St Petersburg, Russian Federation

Status

Recruiting

Address

City Hospital #26

St Petersburg, , 196247

LLC International Medical Centre "SOGAZ", St-Petersburg, Russian Federation

Status

Recruiting

Address

LLC International Medical Centre "SOGAZ"

St-Petersburg, , 198035

St. Petersburg, Russian Federation

Status

Recruiting

Address

FSMEI HPE "Military Medical Academy n.a. S.M.Kirov"of Minist

St. Petersburg, , 194044

St. Petersburg, Russian Federation

Status

Not yet recruiting

Address

St. Petersburg State Health Care Institution; Pokrovskaya city Hospital

St. Petersburg, , 199106

Stavropol, Russian Federation

Status

Recruiting

Address

Stavropol Regional Clinical Diagnostic Consultative Center

Stavropol, , 355017

Clinical Center of Serbia, Belgrade, Serbia

Status

Terminated

Address

Clinical Center of Serbia

Belgrade, , 11000

Clinical Center Zvezdara, Belgrade, Serbia

Status

Recruiting

Address

Clinical Center Zvezdara

Belgrade, , 11000

Belgrade, Serbia

Status

Withdrawn

Address

Clinical Center " Dr Dragisa Misovic Dedinje"

Belgrade, , 11040

Military Medical Academy, Belgrade, Serbia

Status

Recruiting

Address

Military Medical Academy

Belgrade, , 11040

Clinical Center Bezanijska Kosa, Belgrade, Serbia

Status

Recruiting

Address

Clinical Center Bezanijska Kosa

Belgrade, , 11070

Clinical Center Zemun, Belgrade, Serbia

Status

Recruiting

Address

Clinical Center Zemun

Belgrade, , 11080

Clinical Center Kragujevac, Kragujevac, Serbia

Status

Recruiting

Address

Clinical Center Kragujevac

Kragujevac, , 34000

Clinical Center Nis, NIS, Serbia

Status

Recruiting

Address

Clinical Center Nis

NIS, , 18000

Health Center Valjevo, Valjevo, Serbia

Status

Withdrawn

Address

Health Center Valjevo

Valjevo, , 14000

Zrenjanin, Serbia

Status

Recruiting

Address

General Hospital "Djordje Joanovic"; Gastroenterology

Zrenjanin, , 23000

Banska Bystrica, Slovakia

Status

Recruiting

Address

Fakultna nemocnica s poliklinikou F.D. Roosevelta

Banska Bystrica, , 974 01

Bratislava, Slovakia

Status

Withdrawn

Address

Univerzitna nemocnica Bratislava, Nemocnica sv. Cyrila a Metoda

Bratislava, , 85107

Lucenec, Slovakia

Status

Terminated

Address

Vseobecna nemocnica s poliklinikou Lucenec n.o.

Lucenec, , 98401

KM Management spol. s r.o., Nitra, Slovakia

Status

Recruiting

Address

KM Management spol. s r.o.

Nitra, , 94901

Gastro I, s.r.o., Presov, Slovakia

Status

Recruiting

Address

Gastro I, s.r.o.

Presov, , 08001

Svet zdravia a.s., Rimavska Sobota, Slovakia

Status

Recruiting

Address

Svet zdravia a.s.

Rimavska Sobota, , 97901

Frantisek Horvath- GEA, Sahy, Slovakia

Status

Recruiting

Address

Frantisek Horvath- GEA

Sahy, , 93601

Kharkiv, Kharkiv Governorate, Ukraine

Status

Recruiting

Address

CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 of KCC

Kharkiv, Kharkiv Governorate, 61037

Kharkiv, Kharkiv Governorate, Ukraine

Status

Recruiting

Address

CI of Healthcare Kharkiv Reg Clin Hosp-Center of Med Emergency & Accident Medicine

Kharkiv, Kharkiv Governorate, 61204

Kyiv, Kharkiv Governorate, Ukraine

Status

Recruiting

Address

Communal Institution of Kyiv Regional Council Kyiv Regional Clinical Hospital

Kyiv, Kharkiv Governorate, 04107

Kyiv, KIEV Governorate, Ukraine

Status

Recruiting

Address

Medical Center of Limited Liability Company Medical Clinic Blagomed

Kyiv, KIEV Governorate, 1023

Kyiv, KIEV Governorate, Ukraine

Status

Recruiting

Address

CI of Kyiv RC Regional Clinical Hospital #2

Kyiv, KIEV Governorate, 4073

CI City Hospital #1, Zaporizhzhia, Tavria Okruha, Ukraine

Status

Recruiting

Address

CI City Hospital #1

Zaporizhzhia, Tavria Okruha, 69104

Chernivtsi, Ukraine

Status

Recruiting

Address

RCI Chernivtsi RCH Gastroenterology Bukovinsky SMU

Chernivtsi, , 58002

Ivano-Frankivsk, Ukraine

Status

Terminated

Address

Ivano-Frankivsk CCH #1; Dep of Surgery SHEI Ivano-Frankivsk NMU

Ivano-Frankivsk, , 76014

CHI Kharkiv City Clinical Hospital #13, Kharkiv, Ukraine

Status

Recruiting

Address

CHI Kharkiv City Clinical Hospital #13

Kharkiv, , 61124

Kyiv, Ukraine

Status

Recruiting

Address

CNI Consultative and Diagnostic Center of Desnianskyi District of Kyiv

Kyiv, , 02232

Kyiv, Ukraine

Status

Withdrawn

Address

P.L. Shupyk NMA of PGE Chair of Gastroenterology, Dietology & Endoscopy BO Kyiv CCH #8

Kyiv, , 04201

Poltava, Ukraine

Status

Recruiting

Address

M.V. Sklifosovskyi Poltava RCH Outpatient UMSA HSEIU Ukrainian Medical Stomatological Academy

Poltava, , 36011

Uzhgorod, Ukraine

Status

Not yet recruiting

Address

SI Divisional Clinical Hospital of Uzhgorod Station of ST&BA LZ Dep of Therapy SHEI Uzhgorod NU

Uzhgorod, , 88009

CI City Hospital #7, Zaporizhzhia, Ukraine

Status

Recruiting

Address

CI City Hospital #7

Zaporizhzhia, , 69118

Zaporizhzhia, Ukraine

Status

Withdrawn

Address

CI Zaporizhzhia Regional Clinical Hospital of ZRC

Zaporizhzhia, , 69600

Ciudad Autonoma Buenos Aires, Argentina

Status

Withdrawn

Address

Hospital General de Agudos Dr. Cosme Argerich

Ciudad Autonoma Buenos Aires, , 1157

Instituto Medico DAMIC, Cordoba, Argentina

Status

Recruiting

Address

Instituto Medico DAMIC

Cordoba, , X5003DCE

Hospital Provincial del Centenario, Rosario, Argentina

Status

Terminated

Address

Hospital Provincial del Centenario

Rosario, , 2000

Rosario, Argentina

Status

Terminated

Address

Instituto Medico de la Fundacion Estudios Clinicos

Rosario, , 2000

Instituto CAICI, Rosario, Argentina

Status

Withdrawn

Address

Instituto CAICI

Rosario, , S2000CVB

Bankstown-Lidcombe Hospital, Bankstown, New South Wales, Australia

Status

Recruiting

Address

Bankstown-Lidcombe Hospital

Bankstown, New South Wales, 2200

Royal Brisbane and Women's Hospital, Herston, Queensland, Australia

Status

Recruiting

Address

Royal Brisbane and Women's Hospital

Herston, Queensland, 4029

Mater Hospital Brisbane, South Brisbane, Queensland, Australia

Status

Recruiting

Address

Mater Hospital Brisbane

South Brisbane, Queensland, 4101

Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Status

Recruiting

Address

Princess Alexandra Hospital

Woolloongabba, Queensland, 4102

Launceston, Tasmania, Australia

Status

Terminated

Address

Launceston General Hospital; Gastroenterology Research

Launceston, Tasmania, 7250

Monash Medical Centre, Clayton, Victoria, Australia

Status

Active, not recruiting

Address

Monash Medical Centre

Clayton, Victoria, 3168

Emeritus Research, Malvern East, Victoria, Australia

Status

Terminated

Address

Emeritus Research

Malvern East, Victoria, 3145

St Frances Xavier Cabrini Hospital, Malvern, Victoria, Australia

Status

Terminated

Address

St Frances Xavier Cabrini Hospital

Malvern, Victoria, 3144

Parkville, Victoria, Australia

Status

Recruiting

Address

Royal Melbourne Hospital; Department of Colorectal Medicine and Genetics

Parkville, Victoria, 3050

Fiona Stanley Hospital, Murdoch, Western Australia, Australia

Status

Recruiting

Address

Fiona Stanley Hospital

Murdoch, Western Australia, 6150

Brasilia, DF, Brazil

Status

Recruiting

Address

L2IP - Instituto de Pesquisas Clínicas Ltda.

Brasilia, DF, 70200-730

Goiânia, GO, Brazil

Status

Recruiting

Address

Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda

Goiânia, GO, 74535-170

Curitiba, PR, Brazil

Status

Withdrawn

Address

Hospital Nossa Senhora Das Graças; Servico De Gastroenterologica

Curitiba, PR, 80810-040

Rio de Janeiro, RJ, Brazil

Status

Recruiting

Address

Hospital Universitário Clementino Fraga Filho - UFRJ

Rio de Janeiro, RJ, 21941-913

Rio de Janeiro, RJ, Brazil

Status

Recruiting

Address

CCBR Brasil Centro de Pesquisas e Análises Clínicas Ltda.

Rio de Janeiro, RJ, 22271-100

Hospital das Clinicas - UFRGS, Porto Alegre, RS, Brazil

Status

Recruiting

Address

Hospital das Clinicas - UFRGS

Porto Alegre, RS, 90035-003

Botucatu, SP, Brazil

Status

Recruiting

Address

UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu

Botucatu, SP, 18618-970

MHAT Kaspela; EOOD, Plovdiv, Bulgaria

Status

Withdrawn

Address

MHAT Kaspela; EOOD

Plovdiv, , 4002

Fifth MHAT - Sofia EAD, Sofia, Bulgaria

Status

Terminated

Address

Fifth MHAT - Sofia EAD

Sofia, , 1233

Sofia, Bulgaria

Status

Terminated

Address

National Multiprofile Hospital Tsar Boris III

Sofia, , 1233

DCC "Sarce i Zdrave", OOD, Sofia, Bulgaria

Status

Terminated

Address

DCC "Sarce i Zdrave", OOD

Sofia, , 1407

UMHAT "Sv. Ivan Rilski", EAD, Sofia, Bulgaria

Status

Recruiting

Address

UMHAT "Sv. Ivan Rilski", EAD

Sofia, , 1431

UMHAT Tsaritsa Yoanna - ISUL, EAD, Sofia, Bulgaria

Status

Recruiting

Address

UMHAT Tsaritsa Yoanna - ISUL, EAD

Sofia, , 1527

Military Medical Academy - MHAT - Sofia, Sofia, Bulgaria

Status

Terminated

Address

Military Medical Academy - MHAT - Sofia

Sofia, , 1606

MC "Health BG", EOOD, Sofia, Bulgaria

Status

Terminated

Address

MC "Health BG", EOOD

Sofia, , 1680

MHAT SofiaMed; OOD, Sofia, Bulgaria

Status

Terminated

Address

MHAT SofiaMed; OOD

Sofia, ,

MC Medica Plus, Veliko Tarnovo, Bulgaria

Status

Recruiting

Address

MC Medica Plus

Veliko Tarnovo, , 5000

OÜ Innomedica, Tallinn, Estonia

Status

Recruiting

Address

OÜ Innomedica

Tallinn, , 10117

East Tallinn Central Hospital, Tallinn, Estonia

Status

Recruiting

Address

East Tallinn Central Hospital

Tallinn, , 10138

West Tallinn Central Hospital, Tallinn, Estonia

Status

Recruiting

Address

West Tallinn Central Hospital

Tallinn, , 10617

North Estonia Medical Centre Foundation, Tallinn, Estonia

Status

Recruiting

Address

North Estonia Medical Centre Foundation

Tallinn, , 13419

Tartu University Hospital, Tartu, Estonia

Status

Recruiting

Address

Tartu University Hospital

Tartu, , 51014

Princess Margaret Hospital, Hong Kong, Hong Kong

Status

Recruiting

Address

Princess Margaret Hospital

Hong Kong, ,

Hong Kong, Hong Kong

Status

Recruiting

Address

The University of Hong Kong; Community Medicine

Hong Kong, ,

Tuen Mun Hospital, Hong Kong, Hong Kong

Status

Recruiting

Address

Tuen Mun Hospital

Hong Kong, ,

Guadalajara, Jalisco, Mexico

Status

Recruiting

Address

Centro Integral en Reumatología S.A. de C.V. (CIRSA)

Guadalajara, Jalisco, 44160

Monterrey, Nuevo LEON, Mexico

Status

Not yet recruiting

Address

Hospital San Jose Tec Salud, Fundación Santos y de la Garza Evia, I.B.P.

Monterrey, Nuevo LEON, 64710

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