Study To Evaluate The Efficacy And Safety Of Oral PF-06651600 And PF‑06700841 In Subjects With Moderate To Severe Crohn's Disease

Study Purpose

The objectives of this study are to evaluate the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06651600 (200 mg for 8 weeks followed by 50 mg for 4 weeks) dosed once daily and PF-06700841 (60 mg for 12 weeks) dosed once daily during an induction period of 12 weeks, followed by an open label extension period at doses of 50 mg and 30 mg of PF 06651600 and PF 06700841, respectively, for 52 weeks.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years - 75 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

1. Male and/or female subjects 18 years to 75 years of age 2. Documented diagnosis of ileal, ileocolonic, or colonic CD with a minimum disease duration of 3 months, as determined by endoscopic and histopathology assessment. 3. Endoscopic confirmation of active disease with total SES CD total score of at least 7. For isolated ileal disease, SES CD total score should be at least 4. 4. An average daily liquid/soft stool frequency (SF) greater than or equal to 2.5 or daily abdominal pain (AP) greater than or equal to 2.0. 5. Must have inadequate response to, loss of response to, or intolerance to at least one conventional therapy for CD: •Steroids; Immunosuppressants (azathioprine [AZA], 6 MP, or methotrexate [MTX]); Anti TNF inhibitors (infliximab, adalimumab,certolizumab); Anti integrin inhibitors (eg, vedolizumab); Anti IL 12/23 inhibitor (ustekinumab). 6. Subjects currently receiving the following treatment for CD are eligible providing they have been on stable doses as described below:
  • - Oral corticosteroids (prednisone or equivalent up to 25 mg/day; budesonide up to 9 mg/day).
Stable dose for at least 2 weeks prior to baseline. If oral corticosteroids have been recently discontinued, they must have been stopped at least 2 weeks prior to baseline. Decreases in steroid use due to AEs are allowed.
  • - Oral 5 ASA or sulfasalazine are allowed providing that the dose is stable for at least 4 weeks prior to baseline.
  • - Crohn's disease related antibiotics are allowed providing that the dose is stable for at least 4 weeks prior to baseline.
If antibiotics are stopped prior to baseline, they must be discontinued at least 4 days prior to baseline.

Exclusion Criteria:

1. Diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, infectious colitis, radiation colitis, diverticular disease, ulcerative colitis (UC), or clinical findings suggestive of UC. 2. Presence of active (draining) fistulae or intra abdominal or perineal abscesses. 3. Strictures with obstructive symptoms. 4. Short bowel syndrome. 5. History of bowel perforation requiring surgical intervention within the past 12 months. 6. Previous bowel surgery resulting in an existing stoma. Subjects who have a j pouch are excluded, as a j pouch can result in a stoma. 7. History of bowel surgery within 6 months prior to baseline. 8. Subjects displaying clinical signs of fulminant colitis or toxic megacolon. 9. Subjects with primary sclerosing cholangitis. 10. Subjects with evidence of colonic adenomas, dysplasia or neoplasia. 11. Abnormal findings on the chest x ray film such as presence of tuberculosis (TB), general infections, heart failure, or malignancy. 12. Any history of either untreated or inadequately treated latent or active TB infection, current treatment for active or latent TB infection or evidence of currently active TB by chest x ray, residing with or frequent close contact with individual(s) with active TB. 13. Subjects receiving the following therapies within the time period described below or expected to receive any of these therapies during the study period: 1. >9 mg/day of oral budesonide or >25 mg/day of prednisone or equivalent oral systemic corticosteroid dose within 2 weeks prior to baseline. 2. IV, IM (parenteral), or topical (rectal) treatment of 5 ASA or corticosteroid enemas/suppositories within 2 weeks prior to baseline. 3. Azathioprine, 6 mercaptopurine, or methotrexate within 2 weeks prior to baseline. 4. Anti TNF inhibitors (or biosimilars thereof) as described below:
  • - Infliximab within 8 weeks prior to baseline; - Adalimumab within 8 weeks prior to baseline; - Certolizumab within 8 weeks prior to baseline; 5.
Anti integrin inhibitors (eg, vedolizumab) within 8 weeks prior to baseline. 6. Ustekinumab within 8 weeks prior to baseline. 7. Interferon therapy within 8 weeks prior to baseline. 8. Subjects with prior treatment with lymphocyte depleting agents/therapies within 1 year prior to baseline (eg, CamPath[alemtuzumab], alkylating agents [eg, cyclophosphamide or chlorambucil], total lymphoid irradiation, etc). 9. Subjects who have received rituximab or other selective B lymphocyte depleting agents within 1 year prior to baseline. 10. Subjects previously receiving leukocyte apheresis, including selective lymphocyte, monocyte, or granulocyte apheresis, or plasma exchange within 6 months prior to baseline. 11. Other marketed immunosuppressants or biologics with immunomodulatory properties within 3 months prior to baseline. 12. Subjects who have received other JAK inhibitors within 3 months prior to baseline. 13. Subjects who have not responded to or have been intolerant of other JAK inhibitors. 14. Other investigational procedures(s) or product(s), such as immunosuppressants used in transplantation (eg, mycophenolate mofetil, cyclosporine, rapamycin, or tacrolimus) or live (attenuated) vaccine within 30 days prior to baseline.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT03395184
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Pfizer
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Pfizer CT.gov Call Center
Principal Investigator Affiliation Pfizer
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Australia, Austria, Belgium, Bosnia and Herzegovina, Canada, Croatia, Czechia, Georgia, Germany, Hungary, Italy, Korea, Republic of, Lebanon, Poland, Russian Federation, Saudi Arabia, Serbia, Slovakia, South Africa, Spain, Switzerland, Tunisia, Turkey, Ukraine, United Arab Emirates, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Crohn's Disease
Study Website: View Trial Website
Arms & Interventions

Arms

Experimental: PF-06700841 or placebo

Experimental: PF-06651600 or placebo

Interventions

Drug: - Placebo PF-06651600

12 weeks, followed by PF-06651600, 50 mg QD for 52 weeks

Drug: - Placebo PF-06700841

12 weeks, followed by PF-06700841, 30 mg QD for 52 weeks.

Drug: - PF-06651600

200 mg QD for 8 weeks, followed by 50 mg QD up to 56 weeks

Drug: - PF-06700841

60 mg QD for 12 weeks followed by 30 mg QD for up to 52 weeks

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Dothan Surgery Center, Dothan, Alabama

Status

Recruiting

Address

Dothan Surgery Center

Dothan, Alabama, 36301

Dothan, Alabama

Status

Recruiting

Address

Gut P.C., dba Digestive Health Specialists of the Southeast

Dothan, Alabama, 36305

Brighton Surgical Center, Beverly Hills, California

Status

Recruiting

Address

Brighton Surgical Center

Beverly Hills, California, 90210

Long Beach Clinical Trial Services, Inc., Long Beach, California

Status

Recruiting

Address

Long Beach Clinical Trial Services, Inc.

Long Beach, California, 90806

Entertainment Medical Group, Los Angeles, California

Status

Recruiting

Address

Entertainment Medical Group

Los Angeles, California, 90036

Los Angeles, California

Status

Recruiting

Address

Gastrointestinal Biosciences Clinical Trials, LLC

Los Angeles, California, 90067

Alliance Clinical Research, LLC, Poway, California

Status

Recruiting

Address

Alliance Clinical Research, LLC

Poway, California, 92064

Front Range Endoscopy Center, Colorado Springs, Colorado

Status

Recruiting

Address

Front Range Endoscopy Center

Colorado Springs, Colorado, 80903

Peak Gastroenterology Associates, Colorado Springs, Colorado

Status

Recruiting

Address

Peak Gastroenterology Associates

Colorado Springs, Colorado, 80907

Gastro Florida, Clearwater, Florida

Status

Recruiting

Address

Gastro Florida

Clearwater, Florida, 33756-3839

West Coast Endoscopy Center, Clearwater, Florida

Status

Recruiting

Address

West Coast Endoscopy Center

Clearwater, Florida, 33756

Gastro Florida, Clearwater, Florida

Status

Recruiting

Address

Gastro Florida

Clearwater, Florida, 33762

Jacksonville, Florida

Status

Not yet recruiting

Address

UF Health Jacksonville - Gastroenterology Emerson

Jacksonville, Florida, 32207

UF Health Jacksonville - Faculty Clinic, Jacksonville, Florida

Status

Not yet recruiting

Address

UF Health Jacksonville - Faculty Clinic

Jacksonville, Florida, 32209

Miami, Florida

Status

Recruiting

Address

University of Miami Clinical Research Building

Miami, Florida, 33136

Miami, Florida

Status

Recruiting

Address

University of Miami Crohn's and Colitis Center

Miami, Florida, 33136

University of Miami Hospital and Clinics, Miami, Florida

Status

Recruiting

Address

University of Miami Hospital and Clinics

Miami, Florida, 33136

University of Miami Hospital, Miami, Florida

Status

Recruiting

Address

University of Miami Hospital

Miami, Florida, 33136

Millenia Surgery Center, Orlando, Florida

Status

Terminated

Address

Millenia Surgery Center

Orlando, Florida, 32811

HMD Research LLC, Orlando, Florida

Status

Terminated

Address

HMD Research LLC

Orlando, Florida, 32819

Treasure Valley Medical Research, Boise, Idaho

Status

Recruiting

Address

Treasure Valley Medical Research

Boise, Idaho, 83706

Shawnee Mission, Kansas

Status

Recruiting

Address

WestGlen Gastrointestinal Consultants, P.A.

Shawnee Mission, Kansas, 66217

CroNOLA, LLC, Houma, Louisiana

Status

Recruiting

Address

CroNOLA, LLC

Houma, Louisiana, 70360

Gulf Coast Surgical Center, Houma, Louisiana

Status

Recruiting

Address

Gulf Coast Surgical Center

Houma, Louisiana, 70360

The Hearing Center (Audiology), Houma, Louisiana

Status

Recruiting

Address

The Hearing Center (Audiology)

Houma, Louisiana, 70360

Chevy Chase Endoscopy Center, Chevy Chase, Maryland

Status

Recruiting

Address

Chevy Chase Endoscopy Center

Chevy Chase, Maryland, 20815

Chevy Chase, Maryland

Status

Recruiting

Address

MGG Group Co., Inc., Chevy Chase Clinical Research

Chevy Chase, Maryland, 20815

Capitol Research, Rockville, Maryland

Status

Recruiting

Address

Capitol Research

Rockville, Maryland, 20850

Brigham and Women's Hospital, Boston, Massachusetts

Status

Recruiting

Address

Brigham and Women's Hospital

Boston, Massachusetts, 02115

Mass Eye and Ear, Longwood, Boston, Massachusetts

Status

Recruiting

Address

Mass Eye and Ear, Longwood

Boston, Massachusetts, 02115

Brigham and Women's Hospital, Boston, Massachusetts

Status

Recruiting

Address

Brigham and Women's Hospital

Boston, Massachusetts, 02215

Brigham and Women's Hospital, Chestnut Hill, Massachusetts

Status

Recruiting

Address

Brigham and Women's Hospital

Chestnut Hill, Massachusetts, 02467

UMass Memorial Medical Center, Worcester, Massachusetts

Status

Recruiting

Address

UMass Memorial Medical Center

Worcester, Massachusetts, 01655

Worcester, Massachusetts

Status

Recruiting

Address

University of Massachusetts Medical School

Worcester, Massachusetts, 01655

Caro Health Plaza, Caro, Michigan

Status

Recruiting

Address

Caro Health Plaza

Caro, Michigan, 48723

Chesterfield, Michigan

Status

Recruiting

Address

Clinical Research Institute of Michigan, LLC

Chesterfield, Michigan, 48047

Eastside Endoscopy Center, Macomb, Michigan

Status

Recruiting

Address

Eastside Endoscopy Center

Macomb, Michigan, 48044

Eastside Endoscopy Center, Saint Clair Shores, Michigan

Status

Recruiting

Address

Eastside Endoscopy Center

Saint Clair Shores, Michigan, 48081

Digestive Health Center, Ocean Springs, Mississippi

Status

Not yet recruiting

Address

Digestive Health Center

Ocean Springs, Mississippi, 39564

New York, New York

Status

Recruiting

Address

Weill Cornell Medical College (Clinical Site)

New York, New York, 10021

Weill Cornell Medical College, New York, New York

Status

Recruiting

Address

Weill Cornell Medical College

New York, New York, 10021

New York, New York

Status

Recruiting

Address

New York Presbyterian Hospital - Weill Cornell Medical College (Colonoscopy)

New York, New York, 10065

New York, New York

Status

Recruiting

Address

New York Presbyterian Hospital - Weill Cornell Medical College Investigational Pharmacy

New York, New York, 10065

New York, New York

Status

Recruiting

Address

Weill Cornell Medical College - New York Presbyterian Hospital (Endoscopy Suite)

New York, New York, 10065

New York, New York

Status

Recruiting

Address

Weill Cornell Medical College - New York Presbyterian Hospital

New York, New York, 10065

North Massapequa, New York

Status

Recruiting

Address

DiGiovanna Institute for Medical Education And Research

North Massapequa, New York, 11758-1853

UNC Hospitals, Chapel Hill, North Carolina

Status

Recruiting

Address

UNC Hospitals

Chapel Hill, North Carolina, 27514

Chapel Hill, North Carolina

Status

Recruiting

Address

UNC Hospitals Endoscopy Center at Meadowmont

Chapel Hill, North Carolina, 27517

Chapel Hill, North Carolina

Status

Recruiting

Address

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599

Winston-Salem, North Carolina

Status

Recruiting

Address

Gastroenterology Associates of the Piedmont, PA

Winston-Salem, North Carolina, 27103

PMG Research of Winston-Salem, LLC, Winston-Salem, North Carolina

Status

Recruiting

Address

PMG Research of Winston-Salem, LLC

Winston-Salem, North Carolina, 27103

Digestive Disease Specialists, Inc., Oklahoma City, Oklahoma

Status

Not yet recruiting

Address

Digestive Disease Specialists, Inc.

Oklahoma City, Oklahoma, 73112

Holston Medical Group, Kingsport, Tennessee

Status

Terminated

Address

Holston Medical Group

Kingsport, Tennessee, 37660

Holston Valley Surgery Center, Kingsport, Tennessee

Status

Terminated

Address

Holston Valley Surgery Center

Kingsport, Tennessee, 37660

Vanderbilt University Medical Center, Nashville, Tennessee

Status

Recruiting

Address

Vanderbilt University Medical Center

Nashville, Tennessee, 37212-1375

Vanderbilt University Medical Center, Nashville, Tennessee

Status

Recruiting

Address

Vanderbilt University Medical Center

Nashville, Tennessee, 37212-1610

Nashville, Tennessee

Status

Recruiting

Address

Vanderbilt University Medical Center - GI Endoscopy Lab

Nashville, Tennessee, 37232-5543

Vanderbilt University Medical Center, Nashville, Tennessee

Status

Recruiting

Address

Vanderbilt University Medical Center

Nashville, Tennessee, 37232-7610

Nashville, Tennessee

Status

Recruiting

Address

Vanderbilt University Medical Center - GI Research Regulatory

Nashville, Tennessee, 37232

Arlington, Texas

Status

Recruiting

Address

Cross Timbers Surgery Center L.P. (Colonoscopy)

Arlington, Texas, 76012

Envision Imaging (CXR), Arlington, Texas

Status

Recruiting

Address

Envision Imaging (CXR)

Arlington, Texas, 76012

Texas Clinical Research Institiute, LLC, Arlington, Texas

Status

Recruiting

Address

Texas Clinical Research Institiute, LLC

Arlington, Texas, 76012

First Street Hospital, Bellaire, Texas

Status

Recruiting

Address

First Street Hospital

Bellaire, Texas, 77401

First Street Surgical Center, Bellaire, Texas

Status

Recruiting

Address

First Street Surgical Center

Bellaire, Texas, 77401

Pearland Surgery Center, Houston, Texas

Status

Recruiting

Address

Pearland Surgery Center

Houston, Texas, 77047

Lonestar Endoscopy, LLP, Southlake, Texas

Status

Recruiting

Address

Lonestar Endoscopy, LLP

Southlake, Texas, 76092

Texas Digestive Disease Consultants, Southlake, Texas

Status

Recruiting

Address

Texas Digestive Disease Consultants

Southlake, Texas, 76092

Verity Research, Inc., Fairfax, Virginia

Status

Recruiting

Address

Verity Research, Inc.

Fairfax, Virginia, 22031

International Sites

Concord Repatriation General Hospital, Concord, New South Wales, Australia

Status

Recruiting

Address

Concord Repatriation General Hospital

Concord, New South Wales, 2139

Mater Misericordiae Ltd, South Brisbane, Queensland, Australia

Status

Recruiting

Address

Mater Misericordiae Ltd

South Brisbane, Queensland, 4101

Ballarat Base Hospital, Ballarat, Victoria, Australia

Status

Active, not recruiting

Address

Ballarat Base Hospital

Ballarat, Victoria, 3350

Saint John of God Health Care Inc., Subiaco, Western Australia, Australia

Status

Recruiting

Address

Saint John of God Health Care Inc.

Subiaco, Western Australia, 6008

Wien, Austria

Status

Recruiting

Address

AKH Wien Universitaetsklinik fuer Innere Medizin III

Wien, , 1090

University Hospital Brussels, Jette, Belgium

Status

Recruiting

Address

University Hospital Brussels

Jette, , 1090

University Hospitals Leuven, Leuven, Belgium

Status

Recruiting

Address

University Hospitals Leuven

Leuven, , 3000

CHC MontLégia, Liège, Belgium

Status

Recruiting

Address

CHC MontLégia

Liège, ,

Banja Luka, Bosnia and Herzegovina

Status

Recruiting

Address

Javna zdravstvena ustanova Univerzitetski klinicki centar Republike Srpske,

Banja Luka, , 78000

Sveucilisna klinicka bolnica Mostar,, Mostar, Bosnia and Herzegovina

Status

Active, not recruiting

Address

Sveucilisna klinicka bolnica Mostar,

Mostar, , 88000

Winnipeg, Manitoba, Canada

Status

Recruiting

Address

Winnipeg Regional Health Authority - Health Sciences Centre, Winnipeg

Winnipeg, Manitoba, R3A 1R9

RocklandMD, Mont-Royal, Quebec, Canada

Status

Not yet recruiting

Address

RocklandMD

Mont-Royal, Quebec, H3P 2V9

Mont-Royal, Quebec, Canada

Status

Not yet recruiting

Address

CMIIM (Le Centre des Maladies Inflammatoires et Intestinales de Montreal)

Mont-Royal, Quebec, H3P 3E5

Montreal, Quebec, Canada

Status

Not yet recruiting

Address

CIUSSS de l'Est-de-l'Ile-de-Montreal Installation Hopital Maisonneuve-Rosemont

Montreal, Quebec, H1T 2M4

Zagreb, Hrvatska, Croatia

Status

Recruiting

Address

Klinicki bolnicki centar Sestre milosrdnice

Zagreb, Hrvatska, 10000

Rijeka, Croatia

Status

Not yet recruiting

Address

Klinicki bolnicki centar Rijeka, Odjel za gastroenterologiju

Rijeka, , 51000

Split, Croatia

Status

Recruiting

Address

Klinicki Bolnicki centar Split, Zavod za gastroenterologiju

Split, , 21000

Zadar, Croatia

Status

Recruiting

Address

Opca bolnica Zadar, Odjel za gastroenterologiju

Zadar, , 23000

Klinicka bolnica Dubrava Zagreb, Zagreb, Croatia

Status

Recruiting

Address

Klinicka bolnica Dubrava Zagreb

Zagreb, , 10000

Zagreb, Croatia

Status

Recruiting

Address

Klinicki bolnicki centar Zagreb, Zavod za gastroenterologiju i hepatologiju

Zagreb, , 10000

Lekarna Altea, Bilina, Czechia

Status

Not yet recruiting

Address

Lekarna Altea

Bilina, , 41801

Nemocnice Horovice, a.s., Horovice, Czechia

Status

Recruiting

Address

Nemocnice Horovice, a.s.

Horovice, , 268 31

Hepato-Gastroenterologie HK s.r.o., Hradec Kralove, Czechia

Status

Recruiting

Address

Hepato-Gastroenterologie HK s.r.o.

Hradec Kralove, , 500 12

Medialpharma s.r.o., Hradec Kralove, Czechia

Status

Recruiting

Address

Medialpharma s.r.o.

Hradec Kralove, , 500 12

Most, Czechia

Status

Not yet recruiting

Address

Gastroenterologicka ambulance a endoskopie

Most, , 43401

Vseobecna fakultni nemocnice, Praha 2, Czechia

Status

Not yet recruiting

Address

Vseobecna fakultni nemocnice

Praha 2, , 128 08

Všeobecná fakultní nemocnice v Praze, Praha 2, Czechia

Status

Not yet recruiting

Address

Všeobecná fakultní nemocnice v Praze

Praha 2, , 128 08

Libera Scientia s.r.o., Praha 3, Czechia

Status

Not yet recruiting

Address

Libera Scientia s.r.o.

Praha 3, , 130 00

Fakultni nemocnice v Motole, Praha 5, Czechia

Status

Not yet recruiting

Address

Fakultni nemocnice v Motole

Praha 5, , 150 06

Fakultní Nemocnice v Motole, Praha 5, Czechia

Status

Not yet recruiting

Address

Fakultní Nemocnice v Motole

Praha 5, , 150 06

Strakonice, Czechia

Status

Recruiting

Address

Nemocnice Strakonice, a.s., Interni oddeleni

Strakonice, , 386 01

Nemocnice Strakonice, a.s., Strakonice, Czechia

Status

Recruiting

Address

Nemocnice Strakonice, a.s.

Strakonice, , 386 29

The First University Clinic of TSMU, Tbilisi, Georgia

Status

Recruiting

Address

The First University Clinic of TSMU

Tbilisi, , 0141

Institute of Clinical Cardiology, Ltd., Tbilisi, Georgia

Status

Not yet recruiting

Address

Institute of Clinical Cardiology, Ltd.

Tbilisi, , 0159

David Tatishvili Medical Center, Tbilisi, Georgia

Status

Recruiting

Address

David Tatishvili Medical Center

Tbilisi, , 0186

Paian MED Research GmbH, Berlin, Germany

Status

Recruiting

Address

Paian MED Research GmbH

Berlin, , 10318

Krankenhaus Waldfriede e.V.,, Berlin, Germany

Status

Recruiting

Address

Krankenhaus Waldfriede e.V.,

Berlin, , 14163

Universitaetsklinikum Bonn, Bonn, Germany

Status

Not yet recruiting

Address

Universitaetsklinikum Bonn

Bonn, , 53127

Universitaetsklinikum Schleswig-Holstein, Kiel, Germany

Status

Not yet recruiting

Address

Universitaetsklinikum Schleswig-Holstein

Kiel, , 24105

Marburg, Germany

Status

Not yet recruiting

Address

Universitätsklinikum Giessen und Marburg GmbH

Marburg, , 35043

Bekescsaba, Hungary

Status

Recruiting

Address

Bekes Megyei Kozponti Korhaz, Rethy Pal Tagkorhaz

Bekescsaba, , 5600

Budapest, Hungary

Status

Recruiting

Address

Semmelweis Egyetem, II. Belgyogyaszati Klinika

Budapest, , 1088

Budapest, Hungary

Status

Terminated

Address

Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak

Budapest, , 1125

Gyula, Hungary

Status

Recruiting

Address

Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz, Endoszkopos Laboratorium

Gyula, , 5700

Clinfan Szolgaltato Kft., Szekszard, Hungary

Status

Recruiting

Address

Clinfan Szolgaltato Kft.

Szekszard, , 7100

Veszprem, Hungary

Status

Not yet recruiting

Address

Csolnoky Ferenc Korhaz Belgyogyaszati Centrum I. Belgyogyaszati Osztaly

Veszprem, , 8200

IRCCS Saverio de Bellis, Castellana Grotte, Bari, Italy

Status

Recruiting

Address

IRCCS Saverio de Bellis

Castellana Grotte, Bari, 70013

A.O.Spedali Civili, Brescia, BS, Italy

Status

Recruiting

Address

A.O.Spedali Civili

Brescia, BS, 25123

Univ. "Magna Graecia" di Catanzaro, Catanzaro, CZ, Italy

Status

Recruiting

Address

Univ. "Magna Graecia" di Catanzaro

Catanzaro, CZ, 88100

ASST Monza, Monza, MB, Italy

Status

Recruiting

Address

ASST Monza

Monza, MB, 20090

Rho, Milano, Italy

Status

Recruiting

Address

ASST Rhodense - Ospedale di Circolo di Rho

Rho, Milano, 20017

Rozzano, Milan, Italy

Status

Recruiting

Address

Istituto Clinico Humanitas IRCCS - IBD Center

Rozzano, Milan, 20089

A.O.U. Policlinico G. Martino, Messina, Italy

Status

Recruiting

Address

A.O.U. Policlinico G. Martino

Messina, , 98125

AOU Policlinico di Modena, Modena, Italy

Status

Recruiting

Address

AOU Policlinico di Modena

Modena, , 41124

Azienda Ospedaliera di Padova, Padova, Italy

Status

Recruiting

Address

Azienda Ospedaliera di Padova

Padova, , 35128

Roma, Italy

Status

Recruiting

Address

Policlinico Universitario Campus Bio-Medico

Roma, , 00128

Rome, Italy

Status

Not yet recruiting

Address

Policlinico Gemelli/Complesso Integrato Columbus

Rome, , 00168

Kyungpook National University Hospital, Daegu, Korea, Korea, Republic of

Status

Recruiting

Address

Kyungpook National University Hospital

Daegu, Korea, 41944

Kyung Hee University Hospital, Seoul, Korea, Republic of

Status

Recruiting

Address

Kyung Hee University Hospital

Seoul, , 02447

Kangbuk Samsung Hospital, Seoul, Korea, Republic of

Status

Not yet recruiting

Address

Kangbuk Samsung Hospital

Seoul, , 03181

Seoul, Korea, Republic of

Status

Not yet recruiting

Address

Severance Hospital, Yonsei University Health System

Seoul, , 03722

Seoul, Korea, Republic of

Status

Not yet recruiting

Address

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, , 06591

Hôtel Dieu de France Hospital, Achrafieh, Beirut, Lebanon

Status

Not yet recruiting

Address

Hôtel Dieu de France Hospital

Achrafieh, Beirut,

Achrafieh, Lebanon

Status

Recruiting

Address

Saint George Hospital University Medical Center

Achrafieh, ,

Beirut, Lebanon

Status

Recruiting

Address

American University of Beirut Medical Center

Beirut, ,

Ain Wazein Medical Village, El Chouf, Lebanon

Status

Recruiting

Address

Ain Wazein Medical Village

El Chouf, ,

Jbeil, Lebanon

Status

Not yet recruiting

Address

Centre Hospitalier Universitaire Notre Dame de Secours

Jbeil, ,

Saida, Lebanon

Status

Recruiting

Address

Hammoud Hospital University Medical Center

Saida, ,

DC-MED Sp. z o.o. Sp.k., Swidnica, Other, Poland

Status

Recruiting

Address

DC-MED Sp. z o.o. Sp.k.

Swidnica, Other, 58-100

H-T. Centrum Medyczne-Endoterapia, Tychy, Silesia, Poland

Status

Recruiting

Address

H-T. Centrum Medyczne-Endoterapia

Tychy, Silesia, 43-100

Katowice, Poland

Status

Recruiting

Address

Niepubliczny Zaklad Opieki Zdrowotnej All-Medicus

Katowice, , 40-659

ETG Kielce, Kielce, Poland

Status

Recruiting

Address

ETG Kielce

Kielce, , 25-355

Knurow, Poland

Status

Recruiting

Address

Indywidualna Specjalistyczna Praktyka Lekarska Maciej Zymla

Knurow, , 44-190

Szpital w Knurowie Sp. z o.o., Knurow, Poland

Status

Recruiting

Address

Szpital w Knurowie Sp. z o.o.

Knurow, , 44-190

Centrum Badan Klinicznych JCI, Krakow, Poland

Status

Recruiting

Address

Centrum Badan Klinicznych JCI

Krakow, , 30-348

Krakow, Poland

Status

Recruiting

Address

Marta Dagmara BANACH Marta Banach Specjalistyczny Gabinet Neurologiczny

Krakow, , 30-539

Centrum Medyczne EVITA, Krakow, Poland

Status

Recruiting

Address

Centrum Medyczne EVITA

Krakow, , 31-153

Krakow, Poland

Status

Recruiting

Address

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.

Krakow, , 31-826

Lodz, Poland

Status

Recruiting

Address

Centrum Medyczne Szpital Swietej Rodziny Sp z o.o.

Lodz, , 90-302

Lodz, Poland

Status

Recruiting

Address

Pracownia Endoskopii Centrum Medyczne Szpital Swietej Rodziny Sp z o.o.

Lodz, , 90-302

Medical Magnus Clinic, Lodz, Poland

Status

Not yet recruiting

Address

Medical Magnus Clinic

Lodz, , 90-552

Lodz, Poland

Status

Not yet recruiting

Address

Wojewodzki Szpital Specjalistyczny im. Bieganskiego w Lodzi

Lodz, , 91-347

Gastromed Sp. z o.o., Lublin, Poland

Status

Recruiting

Address

Gastromed Sp. z o.o.

Lublin, , 20-582

Ai Centrum Medyczne Sp. Z O.O. Sp.K., Poznan, Poland

Status

Recruiting

Address

Ai Centrum Medyczne Sp. Z O.O. Sp.K.

Poznan, , 61-113

Korczowski Bartosz Gabinet Lekarski, Rzeszow, Poland

Status

Not yet recruiting

Address

Korczowski Bartosz Gabinet Lekarski

Rzeszow, , 35-302

ENDOSKOPIA Sp. z o. o., Sopot, Poland

Status

Recruiting

Address

ENDOSKOPIA Sp. z o. o.

Sopot, , 81-756

Sroda Wielkopolska, Poland

Status

Recruiting

Address

Szpital Sredzki Serca Jezusowego sp. z o.o.

Sroda Wielkopolska, , 63-000

Pracownia Endoskopii Szpital MSW, Szczecin, Poland

Status

Recruiting

Address

Pracownia Endoskopii Szpital MSW

Szczecin, , 70-001

Szczecin, Poland

Status

Recruiting

Address

Twoja Przychodnia Szczecinskie Centrum Medyczne

Szczecin, , 71-434

Torun, Poland

Status

Recruiting

Address

Gastromed Kopon, Zmudzinski i Wspolnicy Sp.j.

Torun, , 87-100

Centrum Zdrowia MDM, Warszawa, Poland

Status

Recruiting

Address

Centrum Zdrowia MDM

Warszawa, , 00-635

WIP Warsaw IBD Point Profesor Kierkus, Warszawa, Poland

Status

Recruiting

Address

WIP Warsaw IBD Point Profesor Kierkus

Warszawa, , 00-728

Endoterapia PFG Sp. z o.o., Warszawa, Poland

Status

Recruiting

Address

Endoterapia PFG Sp. z o.o.

Warszawa, , 02-653

Wloclawek, Poland

Status

Recruiting

Address

Centrum Diagnostyczno-Lecznicze Barska Sp. z o. o.

Wloclawek, , 87-800

Melita Medical Sp. z o.o., Wroclaw, Poland

Status

Recruiting

Address

Melita Medical Sp. z o.o.

Wroclaw, , 50-449

Centrum Gastrologiczno Hepatologiczne, Wroclaw, Poland

Status

Recruiting

Address

Centrum Gastrologiczno Hepatologiczne

Wroclaw, , 50-555

Planetmed sp. z.o.o., Wroclaw, Poland

Status

Not yet recruiting

Address

Planetmed sp. z.o.o.

Wroclaw, , 52-210

Lexmedica, Wroclaw, Poland

Status

Recruiting

Address

Lexmedica

Wroclaw, , 53-114

Saint-Petersburg, Sestroretsk, Russian Federation

Status

Recruiting

Address

SPb SBIH "City Hospital #40 of the Kurortnyi region"

Saint-Petersburg, Sestroretsk, 197706

LLC "Alliance Biomedical-Ural Group", Izhevsk, Russian Federation

Status

Recruiting

Address

LLC "Alliance Biomedical-Ural Group"

Izhevsk, , 426061

Clinic of FSBEI HE KSMU MoH RF, Krasnodar, Russian Federation

Status

Not yet recruiting

Address

Clinic of FSBEI HE KSMU MoH RF

Krasnodar, , 350072

LLC "Olla-Med", Moscow, Russian Federation

Status

Recruiting

Address

LLC "Olla-Med"

Moscow, , 105554

Moscow, Russian Federation

Status

Recruiting

Address

Sechenov University on the base of Institute of Translational Medicine and Biotechnology

Moscow, , 119435

Novosibirsk, Russian Federation

Status

Recruiting

Address

Limited Liability Company "Medical Center SibNovoMed"

Novosibirsk, , 630005

Novosibirsk, Russian Federation

Status

Recruiting

Address

Federal State Budgetary Scientific Institution "Scientific Research Institute of Physiology and

Novosibirsk, , 630117

Omsk, Russian Federation

Status

Recruiting

Address

Clinic at FSBEI HE "Omsk State Medical University" MoH RF

Omsk, , 644050

LLC "New Clinic", Pyatigorsk, Russian Federation

Status

Recruiting

Address

LLC "New Clinic"

Pyatigorsk, , 357500

Limited Liability Company "RIAT", Saint-Petersburg, Russian Federation

Status

Recruiting

Address

Limited Liability Company "RIAT"

Saint-Petersburg, , 195220

Saint-Petersburg, Russian Federation

Status

Recruiting

Address

Saint-Petersburg State Budgetary Healthcare Institution "City Hospital #26"

Saint-Petersburg, , 196247

Samara, Russian Federation

Status

Recruiting

Address

Private Institution Educational Organization of Higher Education

Samara, , 443011

Samara, Russian Federation

Status

Recruiting

Address

Non-state Healthcare Institution 'Railway Clinical Hospital at Samara Station of Open Joint Stock

Samara, , 443029

Samara, Russian Federation

Status

Not yet recruiting

Address

Limited Liability Company Medical Company "Hepatolog"

Samara, , 443093

St. Petersburg, Russian Federation

Status

Recruiting

Address

Saint-Petersburg State Budgetary Healthcare Institution "City Clinical Hospital of the Righteous

St. Petersburg, , 197706

King Abdulaziz Medical City, Jeddah, Saudi Arabia

Status

Not yet recruiting

Address

King Abdulaziz Medical City

Jeddah, , 21423

King AbdulAziz Medical City, Riyadh, Saudi Arabia

Status

Not yet recruiting

Address

King AbdulAziz Medical City

Riyadh, , 11426

King Khalid University Hospital, Riyadh, Saudi Arabia

Status

Not yet recruiting

Address

King Khalid University Hospital

Riyadh, , 11472

Zemun, Beograd, Serbia

Status

Recruiting

Address

Klinicko Bolnicki Centar "Bezanijska Kosa"

Zemun, Beograd, 11080

Beograd, Srbija, Serbia

Status

Not yet recruiting

Address

Klinicki Centar Srbije, Klinika za gastroenterohepatologiju

Beograd, Srbija, 11000

Klinicki Centar Kragujevac, Kragujevac, Srbija, Serbia

Status

Recruiting

Address

Klinicki Centar Kragujevac

Kragujevac, Srbija, 34000

Klinicki Centar Nis, Nis, Srbija, Serbia

Status

Not yet recruiting

Address

Klinicki Centar Nis

Nis, Srbija, 18000

Opsta bolnica Subotica, Subotica, Srbija, Serbia

Status

Recruiting

Address

Opsta bolnica Subotica

Subotica, Srbija, 24000

Zrenjanin, Srbija, Serbia

Status

Recruiting

Address

Opsta Bolnica "Djordje Joanovic", Odeljenje Interno, Odsek Gastroenterologija

Zrenjanin, Srbija, 23000

Beograd, Serbia

Status

Not yet recruiting

Address

Klinicko Bolnicki Centar Zvezdara, Klinika za Interne bolesti,

Beograd, , 11000

Beograd, Serbia

Status

Not yet recruiting

Address

Vojnomedicinska akademija, Klinika za gastroenterologiju i hepatologiju

Beograd, , 11000

KBC "Dr Dragisa Misovic-Dedinje", Beograd, Serbia

Status

Not yet recruiting

Address

KBC "Dr Dragisa Misovic-Dedinje"

Beograd, , 11040

Zemun, Beograd, Serbia

Status

Not yet recruiting

Address

Klinicko Bolnicki Centar Zemun, klinika za Internu medicinu,

Zemun, Beograd, , 11080

Banska Bystrica, Slovakia

Status

Recruiting

Address

Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica

Banska Bystrica, , 975 17

Brezno, Slovakia

Status

Not yet recruiting

Address

Breznianske centrum gastroenterologie s.r.o.

Brezno, , 97701

KM Management spol. s.r.o., Nitra, Slovakia

Status

Not yet recruiting

Address

KM Management spol. s.r.o.

Nitra, , 949 01

Sahy, Slovakia

Status

Not yet recruiting

Address

Accout Center s.r.o. Gastroenterologicka ambulancia

Sahy, , 936 01

ENDOMED, s.r.o., Vranov nad Toplou, Slovakia

Status

Recruiting

Address

ENDOMED, s.r.o.

Vranov nad Toplou, , 093 01

Lenasia Clinical Trial Centre, Lenasia, Gauteng, South Africa

Status

Not yet recruiting

Address

Lenasia Clinical Trial Centre

Lenasia, Gauteng, 1827

Wits Clinical Research Trial Site, Parktown, Gauteng, South Africa

Status

Recruiting

Address

Wits Clinical Research Trial Site

Parktown, Gauteng, 2193

Soweto, Gauteng, South Africa

Status

Not yet recruiting

Address

Wits Clinical Reasearch - Wits Bara Clinical Trial Site

Soweto, Gauteng, 2013

Dr Wright Private Practice, Claremont, Western CAPE, South Africa

Status

Not yet recruiting

Address

Dr Wright Private Practice

Claremont, Western CAPE, 7708

Santander, Cantabria, Spain

Status

Recruiting

Address

Hospital Universitario Marques de Valdecilla

Santander, Cantabria, 39008

Hospital Universitario Ramon y Cajal, Madrid, Spain

Status

Recruiting

Address

Hospital Universitario Ramon y Cajal

Madrid, , 28034

Hospital Universitario Virgen del Rocio, Sevilla, Spain

Status

Recruiting

Address

Hospital Universitario Virgen del Rocio

Sevilla, , 41013

Hospital Universitari i Politecnic La Fe, Valencia, Spain

Status

Recruiting

Address

Hospital Universitari i Politecnic La Fe

Valencia, , 46026

Universitätsspital Zürich, Zürich, Switzerland

Status

Recruiting

Address

Universitätsspital Zürich

Zürich, , CH-8091

La Rabta Hospital, Tunis, Tunisia

Status

Recruiting

Address

La Rabta Hospital

Tunis, , 1007

Habib Thameur Hospital, Tunis, Tunisia

Status

Recruiting

Address

Habib Thameur Hospital

Tunis, , 1008

Ankara, Turkey

Status

Not yet recruiting

Address

Ankara Universitesi Tip Fakultesi, Ibn-i Sina Hastanesi, Ic Hastaliklari Anabilim Dali,

Ankara, , 06100

Ankara, Turkey

Status

Not yet recruiting

Address

Ankara Universitesi Tip Fakultesi, Ibn-i Sina Hastanesi

Ankara, , 06100

Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey

Status

Recruiting

Address

Hacettepe Universitesi Tip Fakultesi

Ankara, , 06230

Istanbul, Turkey

Status

Recruiting

Address

Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi

Istanbul, , 34093

Istanbul, Turkey

Status

Not yet recruiting

Address

Istanbul Universitesi Cerrahpasa Tip Facultesi

Istanbul, , 34098

Istanbul, Turkey

Status

Not yet recruiting

Address

Istanbul Universitesi Cerrahpasa Tip Fakultesi

Istanbul, , 34098

Erciyes Universitesi Tip Fakultesi, Kayseri, Turkey

Status

Recruiting

Address

Erciyes Universitesi Tip Fakultesi

Kayseri, , 38039

Kocaeli Universitesi Tip Fakultesi, Kocaeli, Turkey

Status

Not yet recruiting

Address

Kocaeli Universitesi Tip Fakultesi

Kocaeli, , 41380

Mersin, Turkey

Status

Recruiting

Address

Mersin Universitesi Tip Fakultesi Hastanesi, Ic Hastaliklari

Mersin, , 33110

Mersin, Turkey

Status

Recruiting

Address

Mersin Universitesi Tip Fakultesi Hastanesi

Mersin, , 33110

Trabzon, Turkey

Status

Recruiting

Address

Karadeniz Teknik Universitesi Tip Fakultesi, Ic Hastaliklari

Trabzon, , 61080

Trabzon, Turkey

Status

Recruiting

Address

Karadeniz Teknik Universitesi Tip Fakultesi

Trabzon, , 61080

Bulent Ecevit Universitesi Tip Fakultesi, Zonguldak, Turkey

Status

Recruiting

Address

Bulent Ecevit Universitesi Tip Fakultesi

Zonguldak, , 67600

Chernivtsi, Ukraine

Status

Recruiting

Address

Regional Municipal Institution "Chernivtsi Regional Clinical Hospital", gastroenterology department,

Chernivtsi, , 58001

Chernivtsi, Ukraine

Status

Recruiting

Address

Regional Municipal Institution "Chernivtsi Regional Clinical Hospital", Surgery Department

Chernivtsi, , 58001

Kharkiv, Ukraine

Status

Recruiting

Address

Municipal Healthcare Institution Kharkiv City Clinical Hospital #2 n.a. prof. O.O. Shalimov

Kharkiv, , 61037

Kropyvnytskyi, Ukraine

Status

Not yet recruiting

Address

Private Enterprise of Private Manufacturing Company "Acinus", Medical and Diagnostic Center

Kropyvnytskyi, , 25006

Kyiv, Ukraine

Status

Recruiting

Address

Kyiv Municipal Clinical Hospital #18, Proctology Department

Kyiv, , 01030

Kyiv, Ukraine

Status

Recruiting

Address

Medical Center "OK Clinic+" of International Institute of Clinical Trials

Kyiv, , 02091

Kyiv, Ukraine

Status

Recruiting

Address

Medical Center "Universal clinic Oberig" of "Kapital" LLC, Gastro center

Kyiv, , 03680

Kyiv, Ukraine

Status

Recruiting

Address

Municipal Non-profit enterprise of Kyiv Regional Council "Kyiv regional hospital"

Kyiv, , 04078

Lviv, Ukraine

Status

Recruiting

Address

Lviv clinical hospital on Railway Transport of Health Care Center branch of PJSC Ukrainian Railway

Lviv, , 79007

Vinnytsia City Clinical Hospital No.1, Vinnytsia, Ukraine

Status

Recruiting

Address

Vinnytsia City Clinical Hospital No.1

Vinnytsia, , 21000

Vinnytsia, Ukraine

Status

Recruiting

Address

Private Small-Scale Enterprise Medical Center "Pulse"

Vinnytsia, , 21001

Vinnytsia, Ukraine

Status

Recruiting

Address

Vinnytsia Regional Clinical Hospital for War Veterans

Vinnytsia, , 21005

Vinnytsia, Ukraine

Status

Recruiting

Address

Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrohov

Vinnytsia, , 21018

Abu Dhabi, United Arab Emirates

Status

Not yet recruiting

Address

Cleveland Clinica Abu Dhabi, Department of Gastroenterology and Hepatology

Abu Dhabi, , 112412

Al Kuwait Hospital - Dubai, Dubai, United Arab Emirates

Status

Not yet recruiting

Address

Al Kuwait Hospital - Dubai

Dubai, , 22241

Emirates Specialty Hospital, Dubai, United Arab Emirates

Status

Recruiting

Address

Emirates Specialty Hospital

Dubai, , PO BOX 505240

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