A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn's Disease

Study Purpose

The purpose of this study to evaluate the clinical efficacy of guselkumab in fistulizing, perianal Crohn's disease and to assess the overall safety of guselkumab.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Must have a diagnosis of Crohn's disease with a minimum duration of at least 3 months.
  • - Has at least one active draining perianal fistula as a complication of Crohn's disease, confirmed by screening magnetic resonance imaging (MRI) results.
  • - Is naïve to biologics, or demonstrated inadequate response or intolerance to conventional therapies or approved biologic therapies for Crohn's Disease (CD)

    Exclusion Criteria:

    - Has a very severe luminal disease activity.
  • - History of or concurrent rectovaginal fistulas, rectal and/or anal stenosis or other active complications of perianal disease.
  • - Has complications of CD, such as symptomatic strictures or stenoses, short gut syndrome, or any other manifestation that might be anticipated to require surgery or preclude fistula evaluation.
  • - Any medical contraindications preventing study participation.
- Has a history of ongoing, chronic or recurrent enteral or systemic infectious disease

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT05347095
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Janssen-Cilag Ltd.
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Janssen-Cilag Ltd. Clinical Trial
Principal Investigator Affiliation Janssen-Cilag Ltd.
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Australia, Belgium, Canada, Czechia, Egypt, France, Germany, Greece, Hungary, Israel, Italy, Japan, Jordan, Korea, Republic of, Netherlands, Poland, Portugal, Saudi Arabia, Spain, Sweden, Taiwan, Turkey, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Fistulizing Crohns Disease, Perianal Crohns Disease
Additional Details

Crohn's disease is a chronic, progressive, and potentially life-threatening disorder which may affect any part of the gastrointestinal tract. Guselkumab is a fully human immunoglobulin G1 (IgG1) lambda monoclonal antibody (mAb) that binds to the p19 subunit of human interleukin (IL)-23 with high specificity and affinity, without blocking IL-12. The aim is to evaluate the efficacy and safety of guselkumab in the treatment of adult participants with active fistulizing, perianal Crohn's disease who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or biologic therapy or have medical contraindications to such therapies. This study consists of 3 phases: 6 weeks screening phase, 48 weeks treatment phase, and a 16 weeks follow-up phase. The study will have long term extension (LTE) period for participants who complete the 48-week treatment period and in the opinion of the investigator, will continue to benefit from the study intervention. Comprehensive safety data will be collected and the total duration of the study for participants will be up to 118 weeks (including the LTE period).

Arms & Interventions

Arms

Experimental: Group 1: Guselkumab

Participants will receive guselkumab Dose 1 intravenous (IV) infusion followed by Dose 2 subcutaneously (SC). Participants will receive matching placebo to maintain the blind. Participants who are eligible and willing to continue guselkumab may enter the Long-Term Extension (LTE) period and continue to receive guselkumab.

Experimental: Group 2: Guselkumab

Participants will receive guselkumab Dose 1 IV infusion followed by Dose 3 SC. Participants will receive matching placebo to maintain the blind. Participants who are eligible and willing to continue guselkumab may enter the LTE period and continue to receive guselkumab.

Experimental: Group 3: Placebo

Participants will receive placebo IV infusion followed by placebo SC. At Week 24, placebo non-responders will continue to receive guselkumab Dose 4 followed by guselkumab Dose 2 SC. Participants will receive matching placebo to maintain the blind. Participants who are eligible and willing to continue guselkumab may enter the LTE period and continue to receive guselkumab.

Interventions

Drug: - Guselkumab

Guselkumab will be administered subcutaneously/IV infusion.

Drug: - Placebo

Matching placebo will be administered subcutaneously/IV infusion.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

University of Alabama at Birmingham, Birmingham, Alabama

Status

Not yet recruiting

Address

University of Alabama at Birmingham

Birmingham, Alabama, 35294

Yale University, New Haven, Connecticut

Status

Not yet recruiting

Address

Yale University

New Haven, Connecticut, 06510

University of Miami, Miami, Florida

Status

Not yet recruiting

Address

University of Miami

Miami, Florida, 33136

Gastroenterology Group Of Naples, Naples, Florida

Status

Not yet recruiting

Address

Gastroenterology Group Of Naples

Naples, Florida, 34102

Advent Health, Orlando, Florida

Status

Withdrawn

Address

Advent Health

Orlando, Florida, 32803

Morehouse School of Medicine, Atlanta, Georgia

Status

Withdrawn

Address

Morehouse School of Medicine

Atlanta, Georgia, 30310

Atlanta Gastroenterology Associates, Atlanta, Georgia

Status

Not yet recruiting

Address

Atlanta Gastroenterology Associates

Atlanta, Georgia, 30342

Gastroenterology Consultants, Roswell, Georgia

Status

Withdrawn

Address

Gastroenterology Consultants

Roswell, Georgia, 30076

Lexington, Kentucky

Status

Not yet recruiting

Address

University of Kentucky Chandler Medical Center

Lexington, Kentucky, 40536

University of Louisville, Louisville, Kentucky

Status

Not yet recruiting

Address

University of Louisville

Louisville, Kentucky, 40202

Brigham & Women's Hospital, Boston, Massachusetts

Status

Withdrawn

Address

Brigham & Women's Hospital

Boston, Massachusetts, 02115

Washington University School of Medicine, Saint Louis, Missouri

Status

Not yet recruiting

Address

Washington University School of Medicine

Saint Louis, Missouri, 63110

Mount Sinai School of Medicine, New York, New York

Status

Not yet recruiting

Address

Mount Sinai School of Medicine

New York, New York, 10029

Chapel Hill, North Carolina

Status

Withdrawn

Address

The University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599

Digestive Disease Specialists Inc, Oklahoma City, Oklahoma

Status

Recruiting

Address

Digestive Disease Specialists Inc

Oklahoma City, Oklahoma, 73112

Hershey, Pennsylvania

Status

Withdrawn

Address

Penn State Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033

Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania

Status

Not yet recruiting

Address

Allegheny-Singer Research Institute

Pittsburgh, Pennsylvania, 15212-4756

Gastro One, Germantown, Tennessee

Status

Not yet recruiting

Address

Gastro One

Germantown, Tennessee, 38138

Vanderbilt University Medical Center, Nashville, Tennessee

Status

Not yet recruiting

Address

Vanderbilt University Medical Center

Nashville, Tennessee, 37212

Houston Methodist Hospital, Houston, Texas

Status

Not yet recruiting

Address

Houston Methodist Hospital

Houston, Texas, 77030

Gastroenterology Research of San Antonio, San Antonio, Texas

Status

Withdrawn

Address

Gastroenterology Research of San Antonio

San Antonio, Texas, 78229

Texas Digestive Disease Consultants, Southlake, Texas

Status

Withdrawn

Address

Texas Digestive Disease Consultants

Southlake, Texas, 76092

University of Washington, Seattle, Washington

Status

Not yet recruiting

Address

University of Washington

Seattle, Washington, 98195

International Sites

Flinders Medical Centre, Adelaide, Australia

Status

Not yet recruiting

Address

Flinders Medical Centre

Adelaide, , 5042

St Vincent's Hospital - Melbourne, Fitzroy, Australia

Status

Not yet recruiting

Address

St Vincent's Hospital - Melbourne

Fitzroy, , 3065

Liverpool Hospital, Liverpool, Australia

Status

Not yet recruiting

Address

Liverpool Hospital

Liverpool, , 2170

Fiona Stanley Hospital, Murdoch, Australia

Status

Not yet recruiting

Address

Fiona Stanley Hospital

Murdoch, , 6150

Royal Prince Alfred Hospital, Newtown, Australia

Status

Not yet recruiting

Address

Royal Prince Alfred Hospital

Newtown, , 2042

Royal Adelaide Hospital, North Terrace, Australia

Status

Not yet recruiting

Address

Royal Adelaide Hospital

North Terrace, , 5000

Royal Melbourne Hospital, Parkville, Australia

Status

Not yet recruiting

Address

Royal Melbourne Hospital

Parkville, , 3050

Royal Perth Hospital, Perth, Australia

Status

Not yet recruiting

Address

Royal Perth Hospital

Perth, , 6000

Mater Hospital, South Brisbane, Australia

Status

Not yet recruiting

Address

Mater Hospital

South Brisbane, , 4101

St John of God Subiaco Hospital, Subiaco, Australia

Status

Withdrawn

Address

St John of God Subiaco Hospital

Subiaco, , 6008

Hopital Erasme, Bruxelles, Belgium

Status

Not yet recruiting

Address

Hopital Erasme

Bruxelles, , 1070

UZ Gent, Gent, Belgium

Status

Not yet recruiting

Address

UZ Gent

Gent, , 9000

UZ Leuven, Leuven, Belgium

Status

Not yet recruiting

Address

UZ Leuven

Leuven, , 3000

CHU Sart Tilman, Liege, Belgium

Status

Not yet recruiting

Address

CHU Sart Tilman

Liege, , B-4000

London Health Sciences Centre, London, Ontario, Canada

Status

Not yet recruiting

Address

London Health Sciences Centre

London, Ontario, N6A 5A5

Mount Sinai Hospital, Toronto, Ontario, Canada

Status

Not yet recruiting

Address

Mount Sinai Hospital

Toronto, Ontario, M5G 1X5

Toronto, Ontario, Canada

Status

Not yet recruiting

Address

Toronto Immune & Digestive Health Institute Inc.

Toronto, Ontario, M6A 3B4

McGill University Health Centre, Montreal, Quebec, Canada

Status

Not yet recruiting

Address

McGill University Health Centre

Montreal, Quebec, H3G 1A4

Edmonton, Canada

Status

Not yet recruiting

Address

University of Alberta- Ziedler Ledcor Centre

Edmonton, , T6G 2X8

Nemocnice Ceske Budejovice, a.s., Ceske Budejovice, Czechia

Status

Not yet recruiting

Address

Nemocnice Ceske Budejovice, a.s.

Ceske Budejovice, , 37001

Klinicke centrum ISCARE, Praha 9, Czechia

Status

Not yet recruiting

Address

Klinicke centrum ISCARE

Praha 9, , 190 00

Alexandria University Hospital, Alexandria, Egypt

Status

Not yet recruiting

Address

Alexandria University Hospital

Alexandria, , 21131

Cairo, Egypt

Status

Not yet recruiting

Address

National Hepatology and Tropical Medicine Research Institute

Cairo, , 11451

Ain Shams University Hospital, Cairo, Egypt

Status

Not yet recruiting

Address

Ain Shams University Hospital

Cairo, , 11517

Cairo university, Giza, Egypt

Status

Not yet recruiting

Address

Cairo university

Giza, , 12613

Hôpital Beaujon, Clichy, France

Status

Not yet recruiting

Address

Hôpital Beaujon

Clichy, , 92110

CHU de Nice Hopital de l Archet, Nice, France

Status

Not yet recruiting

Address

CHU de Nice Hopital de l Archet

Nice, , 06202

Centre Hospitalier Lyon Sud, Pierre-Bénite, France

Status

Not yet recruiting

Address

Centre Hospitalier Lyon Sud

Pierre-Bénite, , 69495

CHRU Hôpital de Pontchaillou, Rennes, France

Status

Not yet recruiting

Address

CHRU Hôpital de Pontchaillou

Rennes, , 35033

CHU Saint-Etienne - Hôpital Nord, Saint-Priest en Jarez, France

Status

Not yet recruiting

Address

CHU Saint-Etienne - Hôpital Nord

Saint-Priest en Jarez, , 42270

CHRU Nancy-Brabois, Vandoeuvre-les-Nancy, France

Status

Not yet recruiting

Address

CHRU Nancy-Brabois

Vandoeuvre-les-Nancy, , 54511

JWG-University Hospital, Frankfurt, Germany

Status

Not yet recruiting

Address

JWG-University Hospital

Frankfurt, , 60590

Medizinische Hochschule Hannover, Hannover, Germany

Status

Not yet recruiting

Address

Medizinische Hochschule Hannover

Hannover, , 30625

Heidelberg, Germany

Status

Not yet recruiting

Address

Gastroenterology Outpatient Clinic Prof. Ehehalt/Dr. Hemstäd

Heidelberg, , 69121

Kiel, Germany

Status

Not yet recruiting

Address

Universitatsklinikum Schleswig-Holstein - Kiel

Kiel, , 24105

Evangelismos General Hospital of Athens, Athens, Greece

Status

Not yet recruiting

Address

Evangelismos General Hospital of Athens

Athens, , 10676

Hippokration Hospital, Athens, Greece

Status

Not yet recruiting

Address

Hippokration Hospital

Athens, , 11528

University Hospital of Heraklion, Heraklion, Greece

Status

Not yet recruiting

Address

University Hospital of Heraklion

Heraklion, , 71110

Patras University Hospital, Patra, Greece

Status

Not yet recruiting

Address

Patras University Hospital

Patra, , 26504

Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Hungary

Status

Not yet recruiting

Address

Magyar Honvedseg Egeszsegugyi Kozpont

Budapest, , 1062

Semmelweis Egyetem, Budapest, Hungary

Status

Not yet recruiting

Address

Semmelweis Egyetem

Budapest, , 1082

Semmelweis Egyetem, Budapest, Hungary

Status

Not yet recruiting

Address

Semmelweis Egyetem

Budapest, , H-1088

Pecs, Hungary

Status

Not yet recruiting

Address

Pecsi Tudomanyegyetem Orvostudomanyi Es Egeszsegtudomanyi Centrum, I. Belgyogyaszati Klinika

Pecs, , 7624

Rambam Medical Center, Haifa, Israel

Status

Not yet recruiting

Address

Rambam Medical Center

Haifa, , 31096

Shaare Zedek Medical Center, Jerusalem, Israel

Status

Not yet recruiting

Address

Shaare Zedek Medical Center

Jerusalem, , 9103102

Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel

Status

Not yet recruiting

Address

Rabin Medical Center, Beilinson Campus

Petah Tikva, , 4941492

Milano, Italy

Status

Not yet recruiting

Address

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milano, , 20122

Negrar ( Ve), Italy

Status

Not yet recruiting

Address

Ospedale Classificato Equiparato Sacro Cuore Don Calabria di Negrar

Negrar ( Ve), , 37024

Azienda Ospedaliera Universitaria Pisana, Pisa, Italy

Status

Not yet recruiting

Address

Azienda Ospedaliera Universitaria Pisana

Pisa, , 56124

RHO, Italy

Status

Not yet recruiting

Address

Azienda Ospedaliera G.Salvini Ospedale di Rho

RHO, ,

Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

Status

Not yet recruiting

Address

Casa Sollievo della Sofferenza

San Giovanni Rotondo, , 71013

KOKIKAI Tokatsu Tsujinaka Hospital, Abiko, Japan

Status

Not yet recruiting

Address

KOKIKAI Tokatsu Tsujinaka Hospital

Abiko, , 270-1168

Bunkyo-Ku, Japan

Status

Not yet recruiting

Address

Tokyo Medical and Dental University Hospital

Bunkyo-Ku, , 113-8519

Fukuoka University Chikushi Hospital, Chikushino-shi, Japan

Status

Not yet recruiting

Address

Fukuoka University Chikushi Hospital

Chikushino-shi, , 818-8502

Kitakyushu Municipal Medical Center, Fukuoka-ken, Japan

Status

Not yet recruiting

Address

Kitakyushu Municipal Medical Center

Fukuoka-ken, , 802-0077

Fukuoka University Hospital, Fukuoka, Japan

Status

Not yet recruiting

Address

Fukuoka University Hospital

Fukuoka, , 814-0180

Hiroshima University Hospital, Hiroshima-shi, Japan

Status

Not yet recruiting

Address

Hiroshima University Hospital

Hiroshima-shi, , 734-8551

Hukuoka, Japan

Status

Not yet recruiting

Address

Hospital of the University of Occupational and Enviromental Health

Hukuoka, , 807-8555

Sameshima Hospital, Kagoshima, Japan

Status

Not yet recruiting

Address

Sameshima Hospital

Kagoshima, , 892-0846

Nara Medical University Hospital, Kashihara, Japan

Status

Not yet recruiting

Address

Nara Medical University Hospital

Kashihara, , 634-8521

Nagasaki University Hospital, Nagasaki, Japan

Status

Not yet recruiting

Address

Nagasaki University Hospital

Nagasaki, , 852-8501

Kojunkai Daido Clinic, Nagoya, Japan

Status

Not yet recruiting

Address

Kojunkai Daido Clinic

Nagoya, , 457-8511

Nagoya University Hospital, Nagoya, Japan

Status

Not yet recruiting

Address

Nagoya University Hospital

Nagoya, , 466-8560

Nishinomiya, Japan

Status

Not yet recruiting

Address

The Hospital of Hyogo College of Medicine

Nishinomiya, , 663-8501

Okayama University Hospital, Okayama, Japan

Status

Not yet recruiting

Address

Okayama University Hospital

Okayama, , 700-8558

Kinshukai Infusion Clinic, Osaka, Japan

Status

Not yet recruiting

Address

Kinshukai Infusion Clinic

Osaka, , 530-0011

JOHAS Osaka Rosai Hospital, Sakai, Japan

Status

Not yet recruiting

Address

JOHAS Osaka Rosai Hospital

Sakai, , 591-8025

Sapporo Higashi Tokushukai Hospital, Sapporo, Japan

Status

Not yet recruiting

Address

Sapporo Higashi Tokushukai Hospital

Sapporo, , 065-0033

Osaka University Hospital, Suita, Japan

Status

Not yet recruiting

Address

Osaka University Hospital

Suita, , 565-0871

Tokyo Yamate Medical Center, Tokyo, Japan

Status

Not yet recruiting

Address

Tokyo Yamate Medical Center

Tokyo, , 169-0073

Ieda Hospital, Toyota, Japan

Status

Not yet recruiting

Address

Ieda Hospital

Toyota, , 470-1219

Mie University Hospital, Tsu, Japan

Status

Not yet recruiting

Address

Mie University Hospital

Tsu, , 514-8507

Yokkaichi Hazu Medical Center, Yokkaichi, Japan

Status

Not yet recruiting

Address

Yokkaichi Hazu Medical Center

Yokkaichi, , 510-0016

Yokohama, Japan

Status

Not yet recruiting

Address

Yokohama Municipal Citizen's Hospital

Yokohama, , 221-0855

Jordan University Hospital, Amman, Jordan

Status

Not yet recruiting

Address

Jordan University Hospital

Amman, , 11942

Abdali Hospital, Amman, Jordan

Status

Not yet recruiting

Address

Abdali Hospital

Amman, ,

King Abdullah University Hospital, Irbid, Jordan

Status

Not yet recruiting

Address

King Abdullah University Hospital

Irbid, ,

Inje University Haeundae Paik Hospital, Busan, Korea, Republic of

Status

Not yet recruiting

Address

Inje University Haeundae Paik Hospital

Busan, , 48108

Yeungnam University Hospital, Daegu, Korea, Republic of

Status

Not yet recruiting

Address

Yeungnam University Hospital

Daegu, , 42415

Gyeonggi-do, Korea, Republic of

Status

Not yet recruiting

Address

Seoul National University Bundang Hospital

Gyeonggi-do, , 13620

Seoul National University Hospital, Seoul, Korea, Republic of

Status

Not yet recruiting

Address

Seoul National University Hospital

Seoul, , 03080

Seoul, Korea, Republic of

Status

Not yet recruiting

Address

Gangnam Severance Hospital, Yonsei University Health System

Seoul, , 06273

Amsterdam, Netherlands

Status

Not yet recruiting

Address

Academisch Medisch Centrum Universiteit van Amsterdam

Amsterdam, , 1105 AZ

Radboudumc, Nijmegen, Netherlands

Status

Not yet recruiting

Address

Radboudumc

Nijmegen, , 6525 GA

Elisabeth-TweeSteden Ziekenhuis, Tilburg, Netherlands

Status

Not yet recruiting

Address

Elisabeth-TweeSteden Ziekenhuis

Tilburg, , 5022 GC

UMC Utrecht, Utrecht, Netherlands

Status

Not yet recruiting

Address

UMC Utrecht

Utrecht, , 3584 CX

Bialystok, Poland

Status

Not yet recruiting

Address

Gastromed Kralisz Romatowski Stachurska Sp. j.

Bialystok, , 15-322

Bydgoszcz, Poland

Status

Not yet recruiting

Address

Szpital Uniwersytecki nr 2 im. dr. Jana Biziela w Bydgoszczy

Bydgoszcz, , 85-164

Centrum Medyczne Promed, Krakow, Poland

Status

Not yet recruiting

Address

Centrum Medyczne Promed

Krakow, , 31-513

Szczecin, Poland

Status

Not yet recruiting

Address

Twoja Przychodnia - Szczecinskie Centrum Medyczne

Szczecin, , 71-434

WIP Warsaw IBD Point Profesor Kierkus, Warszawa, Poland

Status

Not yet recruiting

Address

WIP Warsaw IBD Point Profesor Kierkus

Warszawa, , 00-728

ETG Zamosc, Zamosc, Poland

Status

Not yet recruiting

Address

ETG Zamosc

Zamosc, , 22-400

Ccab - Hosp. de Braga, Braga, Portugal

Status

Not yet recruiting

Address

Ccab - Hosp. de Braga

Braga, , 4710-243

Chlc - Hosp. Sto Antonio Dos Capuchos, Lisboa, Portugal

Status

Not yet recruiting

Address

Chlc - Hosp. Sto Antonio Dos Capuchos

Lisboa, , G1R 2J6

Hospital Beatriz Angelo, Loures, Portugal

Status

Not yet recruiting

Address

Hospital Beatriz Angelo

Loures, , 2674-514

Porto, Portugal

Status

Not yet recruiting

Address

H. Santo António - Centro Hospitalar do Porto

Porto, , 4099-001

King Fahad Specialist hospital, Dammam, Saudi Arabia

Status

Not yet recruiting

Address

King Fahad Specialist hospital

Dammam, , 31444

King Abdulaziz Medical City, Jeddah, Saudi Arabia

Status

Not yet recruiting

Address

King Abdulaziz Medical City

Jeddah, , 21423

King Abdulaziz Medical City, Jeddah, Saudi Arabia

Status

Not yet recruiting

Address

King Abdulaziz Medical City

Jeddah, , 80200

King Saud University Medical City, Riyadh, Saudi Arabia

Status

Not yet recruiting

Address

King Saud University Medical City

Riyadh, , 11472

Riyadh, Saudi Arabia

Status

Not yet recruiting

Address

King Faisal Specialist Hospital & Research Center

Riyadh, , 12713

Hosp. Clinic I Provincial de Barcelona, Barcelona, Spain

Status

Not yet recruiting

Address

Hosp. Clinic I Provincial de Barcelona

Barcelona, , 08036

Hosp. Arquitecto Marcide, Ferrol, Spain

Status

Not yet recruiting

Address

Hosp. Arquitecto Marcide

Ferrol, , 15405

Hosp. Univ. de La Princesa, Madrid, Spain

Status

Not yet recruiting

Address

Hosp. Univ. de La Princesa

Madrid, , 28006

Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda, Spain

Status

Not yet recruiting

Address

Hosp. Univ. Pta. de Hierro Majadahonda

Majadahonda, , 28222

Hosp. Virgen Macarena, Sevilla, Spain

Status

Not yet recruiting

Address

Hosp. Virgen Macarena

Sevilla, , 41009

Hosp. Univ. Miguel Servet, Zaragoza, Spain

Status

Not yet recruiting

Address

Hosp. Univ. Miguel Servet

Zaragoza, , 50009

Linkoping University Hospital, Linköping, Sweden

Status

Not yet recruiting

Address

Linkoping University Hospital

Linköping, , 581 85

Ersta sjukhus, Stockholm, Sweden

Status

Not yet recruiting

Address

Ersta sjukhus

Stockholm, , 116 91

Danderyds Sjukhus, Stockholm, Sweden

Status

Not yet recruiting

Address

Danderyds Sjukhus

Stockholm, , 182 88

Changhua Christian Hospital, Changhua, Taiwan

Status

Not yet recruiting

Address

Changhua Christian Hospital

Changhua, , 500

Kaohsiung, Taiwan

Status

Not yet recruiting

Address

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung, , 807

Taichung Veterans General Hospital, Taichung, Taiwan

Status

Not yet recruiting

Address

Taichung Veterans General Hospital

Taichung, , 40705

National Taiwan University Hospital, Taipei City, Taiwan

Status

Not yet recruiting

Address

National Taiwan University Hospital

Taipei City, , 10002

Taoyuan City, Taiwan

Status

Not yet recruiting

Address

Chang Gung Memorial Hospital Linkou Branch

Taoyuan City, , 333

Gazi University Medical Faculty, Ankara, Turkey

Status

Not yet recruiting

Address

Gazi University Medical Faculty

Ankara, , 06560

Istanbul, Turkey

Status

Not yet recruiting

Address

Istanbul University Cerrahpasa Medical Faculty

Istanbul, , 34098

Acibadem Kozyatagi Hospital, Istanbul, Turkey

Status

Not yet recruiting

Address

Acibadem Kozyatagi Hospital

Istanbul, , 34734

Ege University Medical Faculty, İzmir, Turkey

Status

Not yet recruiting

Address

Ege University Medical Faculty

İzmir, , 35100

Mersin, Turkey

Status

Not yet recruiting

Address

Mersin University Medical Faculty Hospital

Mersin, , 33110

Belfast, United Kingdom

Status

Not yet recruiting

Address

South Eastern Health and Social Care Trust

Belfast, , BT16 1RH

Birmingham, United Kingdom

Status

Not yet recruiting

Address

University Hospitals Birmingham NHS Foundation Trust

Birmingham, , B15 2GW

Gosforth, United Kingdom

Status

Not yet recruiting

Address

Newcastle upon Tyne Hospitals NHS Foundation Trust

Gosforth, , NE3 3HD

Hull, United Kingdom

Status

Not yet recruiting

Address

Hull University Teaching Hospitals NHS Trust

Hull, , HU3 2JZ

London, United Kingdom

Status

Not yet recruiting

Address

London North West University Healthcare NHS Trust

London, , HA1 3UJ

London, United Kingdom

Status

Not yet recruiting

Address

Guy's and St Thomas' NHS Foundation Trust

London, , SE1 9RT

London, United Kingdom

Status

Not yet recruiting

Address

St George's University Hosptial NHS Foundation Trust

London, , SW17 0QT

Pennine Acute Hospitals NHS Trust, Salford, United Kingdom

Status

Not yet recruiting

Address

Pennine Acute Hospitals NHS Trust

Salford, , M6 8HD

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